 | Prof Michael Detmar Professor of Pharmacogenomics
Swiss Federal Institute of Technology, ETH Zurich |
Background
Michael Detmar obtained his M.D. degree from the University of Freiburg, Germany, in 1984. He performed his clinical training in dermatology at the Free University of Berlin where he was appointed Assistant Professor of Dermatology in 1991. He has been at Harvard Medical School since 1993. In 1998, he was appointed as an Associate Professor of Dermatology at the Massachusetts General Hospital and Harvard Medical School, Boston, USA. In 2004, he was appointed Professor of Pharmacogenomics at the Swiss Federal Institute of Technology, ETH Zurich. His major interests are in the areas of cancer metastasis, psoriasis, skin aging, vascular biology, drug discovery and pharmacogenomics.
He serves as a Section Editor for The Journal of Investigative Dermatology and as Associate Editor for Cancer Research. He is also a member of the Editorial Boards of The Journal of Dermatological Science and of Cancer Biology and Therapy, and he is the European Editor of Lymphatic Research and Biology. He serves as an advisory board member for a number of scientific organizations, foundations and pharmaceutical companies. He has received several scientific awards, including the 2005 Marion B. Sulzberger Memorial Award of the American Academy of Dermatology. He is the author of more than 120 original publications and of several issued patents.
Selected Publications
Skobe M, Hawighorst T, Jackson DG, Prevo R, Janes L, Velasco P, Riccardi L, Alitalo K, Claffey K, Detmar M. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nature Med 2001, 7:192-198.
Skobe M, Hamberg LM, Hawighorst T, Schirner M, Wolf GL, Alitalo K, Detmar M. Concurrent induction of lymphangiogenesis, angiogenesis and macrophage recruitment by VEGF-C in melanoma. Am J Pathol 2001, 159:893-903.
Hawighorst T, Velasco P, Streit M, Kyriakides TR, Brown LF, Bornstein P, Detmar M. Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel anti-tumor host defense mechanism. EMBO J 2001, 20:2631-2640.
Senger DR, Perruzzi C, Streit M, Victor E. Koteliansky VE, de Fougerolles AR, Detmar M. The a1b1 and a2b1 integrins provide critical support for VEGF signaling, endothelial cell migration, and tumor angiogenesis. Am J Pathol 2002, 160:195-204.
Lange-Asschenfeldt B, Weninger W, Velasco P, Kyriakides TR, von Andrian U, Bornstein P, Detmar M. Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2 deficient mice. Blood 2002, 99:538-545.
Hawighorst T, Skobe M, Streit M, Hong Y-K, Velasco P, Brown LF, Riccardi L, Lange-Asschenfeldt B, Detmar M. Activation of the Tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am J Pathol 2002, 160:1381-1392.
Streit M, Stephen AE, Hawighorst T, Matsuda K, Lange-Asschenfeldt B, Brown LF, Vacanti JP, Detmar M. Systemic inhibition of tumor growth and angiogenesis by thrombospondin-2 using cell-based anti-angiogenic gene therapy. Cancer Res 2002, 62:2004-2012.
Oliver G, Detmar M. The rediscovery of the lymphatic system. Old and new insights into the development and biological function of the lymphatic system. Genes & Development 2002, 16:773-783.
Detmar M, Hirakawa S. The formation of lymphatic vessels and its importance in the setting of malignancy. J Exp Med 2002, 196:713-718.
Hawighorst T, Oura H, Streit M, Janes L, Nguyen L, Brown LF, Oliver G, Jackson DG, Detmar M. Thrombospondin -1 selectively inhibits early-stage epithelial carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice. Oncogene 2002, 21: 7945-7956.
Hirakawa S, Hong Y-K, Harvey N, Schacht V, Matsuda K, Libermann T, Detmar M. Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells. Am J Pathol, 2003, 162:575-586.
Oura H, Silva J, Velasco P, Brown LF, Carmeliet P, Detmar M. A critical role of placental growth factor in the induction of inflammation and edema formation. Blood 2003, 101: 560-567.
Dadras SS, Paul T, Bertoncini J, Brown LF, Muzikansky A, Jackson DG, Ellwanger U, Garbe C, Mihm MC, Detmar M. Tumor lymphangiogenesis: A novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol 2003, 162:1951-1960.
Streit M, Detmar M. Angiogenesis, lymphangiogenesis and melanoma metastasis. Oncogene 2003, 22:3172-3179
Schacht V, Ramirez MI, Hong Y-K, Hirakawa S, Feng D, Harvey N, Williams M, Dvorak AM, Dvorak HF, Oliver G, Detmar M. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J 2003, 22:3546-3556.
Yano K, Kajiya K, Yokoyama T, Ishiwata M, Hong YK, Miyakawa T, Detmar M. UVB-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expression. J Invest Dermatol 2004, 122:201-208.
Hong YK, Lange-Asschenfeldt B, Velasco P, Horakawa S, Kunstfeld R, Brown LF, Bohlen P, Senger DR, Detmar M. VEGF-A promotes repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins. FASEB J 2004, 18:1111-1113
Kunstfeld R, Hirakawa S, Hong YK, Schacht V, Lange-Asschenfeldt B, Velasco P, Lin C, Fiebieger E, Wei X, Wu Y, Hicklin D, Bohlen P, Detmar M. Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia. Blood 2004, 104:1048-1057
Hong YK, Foreman K, Shin JW, Hirakawa S, Curry CL, Sage DR, Libermann T, Dezube BJ, Fingeroth JD, Detmar M. Lymphatic re-programming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nature Genetics 2004, 36:683-685.
Hirakawa S., Kodama S., Kunstfeld R., Kajiya K., Brown L.F., and Detmar M. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med 2005, 201: 1089-99
Kajiya K., Hirakawa H., Ma B., Drinnenberg I. Detmar M. Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J 2005, 24: 2885-2895
Dadras S.S., Lange-Asschenfeldt,B., Velasco P., Nguyen L., Vora A., Muzikansky A., Mihm M.C., and Detmar M. Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol 2005,18: 1232-1242
Yano K., Kadoya K., Kajiya K., Hong Y.K., and Detmar M. Ultraviolet B irradiation of human skin induces an angiogenic switch that is mediated by upregulation of vascular endothelial growth factor and by downregulation of thrombospondin-1. Br J Dermatol 2005, 152: 115-121
Schacht V., Dadras S.S., Johnson L.A., Jackson D.G., Hong Y.K., and Detmar M. Upregulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 2005, 166: 913-21
Hirakawa, S., Fujii, S., Kajiya K, Yano, K., Detmar M. Vascular endothelial growth factor promotes sensitivity to ultraviolet-B-induced cutaneous photodamage. Blood 2005, 105: 2392-9
Liersch R., Nay F., Lu L., Detmar M. Induction of lymphatic endothelial cell differentiation in embryoid bodies. Blood 2006, 107:1214-6
Kajiya K., Hirakawa S., Detmar M. (2006) Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function. Am J Pathol, 169: 1496-503
Cueni L., Detmar M. (2006) New insights into the molecular control of the lymphatic vascular system and its role in disease. J Invest Dermatol, 126: 2167-77
Wissmann Ch., Detmar M. (2006) Molecular pathways controlling tumor lymphangiogenesis and lymphatic metastasis. Clin Cancer Res 2006, 12:6865-6868
Kajiya K., Hirakawa S., Detmar M. (2006) Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function. Am J Pathol, 169: 1496-503
Halin C., Detmar M. An unexpected connection: lymph node lymphangiogenesis and dendritic cell migration. Immunity 2006, 24:129-31.
Tobler N., Detmar M. (2006) Tumor and lymph node lymphangiogenesis - impact on cancer metastasis. J Leukocyte Biol, 80: 691-6
Hirakawa S., Brown LF., Kodama S., Paavonen K., Alitalo K., Detmar M. (2006) VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood 2006, Oct 10 (Epub ahead of print)
