2015 Future Leaders Academy Report

5.11.2015 to 7.11.2015

Rome, Italy: 5-7 November 2015

ESDR invited approximately 25 gifted young scientists from dermatological departments in Europe for a 2.5 day meeting early November 2015. The meeting took place in Rome and followed the very successful academies held in Cascais (2011), Barcelona (2012), Florence (2013) and Madrid (2014). The meeting brought together renowned scientists from dermatology and basic science with the brightest young dermatologists working in the field in the past year. All attendees gave oral presentations and there were lectures by invited scientists complementing these presentations. For 2015 the general topic was "Pioneering Skin Research".

The 2015 ESDR Academy for Future Leaders in Dermatology was generously supported through educational grants from Abbvie, Celgene, Lilly and Pfizer

Thursday 5 November 2015

14.00-15.00

Welcome and introduction
Matthias Schmuth (Austria), Michael Hertl (Germany)

15.00-15.20

How I chose and maintain my focus
Marcel Jonkman (The Netherlands)

15.20-16.40

Oral presentations from participants (4):

1. Mutations in SERPINB8 underlie a mild peeling skin phenotype
Manuela Pigors (UK)

2. “Stoned skin" – Role of the (endo)cannabinoid system in cutaneous biology
Attila Olah (Hungary)

3. Langerhans cells and inflammageing in human skin
Suzanne Pilkington (UK)

4. New kids on the block: Innate lymphoid cells in allergy
David Rafei-Shamsabadi (Germany)

16.40-17.00

Coffee Break

17.00-17.20

Relevant animal and cellular models for melanoma
Lionel Larue (France)

17.20-17.40

Bridging research and clinics in rare skin diseases
Giovanna Zambruno (Italy)

17.40-18.40

Oral presentations from participants (2):

1. eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies
Lise Boussemart (France)

2. Comorbidities in Psoriasis
Emmilia Dowlatshahi    (The Netherlands)

 Friday 6 November 2015

08.00-08.20

The non-lesional skin in psoriasis
Zsuzsanna Bata-Csörgő (Hungary)

08.20-08.40

Changing concepts and treatment paradigms in vitiligo
Alain Taïeb (France)

08.40-10.20

Oral presentations from participants (5):

1. The role of Ripoptosome in cell death regulation
Maria Feoktistova (Germany)

2. Is there a role for IL-17E in psoriasis pathogenesis?
Nicolò  Brembilla (Italy)

3. Novel diagnostic tools and markers in inflammatory skin diseases
Natalie Garzorz (Germany)

4. Blocking the activating Fc gamma RIV enhances neutrophil extravasation into the skin in autoantibody-induced tissue injury
Jennifer Klöpper (Germany)

5. The iRHOM2-ADAM17 axis in epidermal hyperproliferation and cancer
Matthew Brooke (UK)

10.20-11.20

Group Photo and Coffee break

11.20-13.00

Oral presentations from participants (5):

1. Infantile haemangioma: pathogenesis, evaluation, and therapy
Sherief Janmohamed (Belgium)

2. The pathomechanism of multifactorial inflammatory diseases: Alterations of the non-lesional skin in psoriasis at the proteome level
Gergely Groma (Hungary)

3. Myeloid cell-restricted Insulin/IGF-1 receptor deficiency protects against skin inflammation
Jana Knüver (Germany)

4. Regulatory T Cells facilitate cutaneous wound healing
Audrey Nosbaum (France)

5. Identification and function of novel skin-specific genes
Peter Arne Gerber (Germany)

14.30-15.00

tba
David Kelsell (UK)

15.00-16.00

Breakout sessions

16.00-16.40

Results from breakout sessions in plenum

Saturday 7 November 2015

08.20-08.40

10 reasons why the hair follicle is the greatest of all study objects in investigative dermatology
Ralf Paus (UK, Germany)

08.40-10.00

Oral presentations from participants (4):

1. Translational vitiligo research: from Koebner's phenomenon to melanocyte-specific immune responses
Reinhart Speeckaert (Belgium)

2. Pharmacogenomic signatures of treatment response in psoriasis
Amy Foulkes (UK)

3. Clinical and genetic heterogeneity of childhood psoriasis
Josefin Lysell (Sweden)

4. Inhibition of BET bromodomains differentially regulates cytokine production in an in vitro inflammation model relevant to psoriasis
Keith Wu (UK)

10.00-11.00

Breakout sessions

11.00-11.40

Results from breakout sessions in plenum

11.40-12.00

Meeting digest and outlook
Matthias Schmuth (Austria), Michael Hertl (Germany)