Journal of Investigative Dermatology RSS feed.
Updated: 2 hours 28 min ago
There are currently no simple, standardized, objective assessments of itch for clinical trials and practice. We sought to validate and test the severity of scratching as an objective measure of itch (4-point ordinal scale ranging from 0 [not present] to 3 [very prominent] based on the observation of scratching lesions). We performed a prospective outpatient study using questionnaires and evaluations by a dermatologist in adults with atopic dermatitis (AD) (n=261). Severity of scratching best correlated with patient-reported global AD severity (Kendal’s Tau=0.336, P<0.0001), Numeric Rating Scale of itch in the past 24 hours (0.266, P=0.0010) and 3 days (0.296, P<0.0001).
Dapsone hypersensitivity syndrome is a rare yet severe adverse drug reaction caused by dapsone, a principal drug in the multidrug therapy for leprosy. HLA-B*13:01 has been identified to be a strong risk factor of dapsone hypersensitivity syndrome, however its low positive predictive value indicated that additional genetic variants may involve in the disease development. To discover contributing genetic variants within HLA loci in addition to HLA-B*13:01, we performed a high coverage next-generation sequencing based HLA typing analysis in 103 dapsone-hypersensitive and 857 dapsone-tolerant HLA-B*13:01 positive leprosy patients in Chinese population.
Inherited forms of Epidermolysis bullosa (EB) are blistering diseases of the skin and mucosa resulting from various gene mutations. Transplantation of bone marrow (BM)-derived stem cells might be a promising systemic treatment for severe dystrophic or junctional EB, but many key questions remain unresolved. Two open questions of clinical interest are whether systemically transplanted BM-derived stem cells of mesodermal origin might be able to transdifferentiate into keratinocytes with an ectodermal phenotype and whether these cells are also capable of repairing a specific intra-epidermal gene defect.
T-oligo, a guanine-rich oligonucleotide (GRO) homologous to the 3'-telomeric overhang of telomeres, elicits potent DNA-damage responses in melanoma cells; however, its mechanism of action is largely unknown. GROs can form G-quadruplexes (G4) which are stabilized by the hydrogen-bonding of guanine residues. In this study, we confirmed the G4-forming capabilities of T-oligo using non-denaturing PAGE, NMR and immunofluorescence. Using an anti-G-quadruplex antibody (BG4) we showed that T-oligo can form G4 in the nuclei of melanoma cells.
Endogenous Glucocorticoid Deficiency in Psoriasis Promotes Inflammation and Abnormal Differentiation
The authors of this study explain that secukinumab has demonstrated significant efficacy with a good safety profile through 1 year in the treatment of plaque psoriasis. They set out to determine the long-term (3-year) efficacy and safety of secukinumab in moderate-to-severe psoriasis. In total, 168 patients receiving secukinumab 300 mg on a fixed-interval schedule, and 172 receiving secukinumab 300 mg retreatment as needed entered this extension study. Secukinumab 300 mg fixed interval sustained high efficacy: at the end of year 3, the proportion of responders achieving ≥ 90% improvement in Psoriasis Area and Severity Index (PASI 90) was 63.8%, with 42.6% achieving PASI 100 response.
Editorial note: Welcome to the Journal of Investigative Dermatology (JID) Snapshot Dx Quiz— In this monthly online-only quiz, the first question (“What is your diagnosis?”) relates to the clinical image above, while additional questions concern the findings reported in a JID article that provides new information about that disease entity.
Editorial note: Welcome to the Journal of Investigative Dermatology (JID) Cells to Surgery Quiz— In this monthly online-only quiz, the first question (“What is your diagnosis?”) relates to the clinical image above, while additional questions concern the findings reported in a JID article that provides new information about that disease entity.
For years, lymph node dissection in breast cancer and melanoma was justified based on the belief that regional lymph nodes are the first sites of metastasis and that distant metastases originate from these metastatic lymph nodes. In a single-center study of 2,299 patients with cutaneous metastatic melanoma, Gassenmaier and colleagues found that development of regional and distant metastases is not a serial process, but that it most likely occurs in parallel. Furthermore, distant metastasis-free and overall survival did not differ between patients with primary hematogenous metastasis and those with primary lymphatic metastasis.
The ultimate purpose of research that we are conducting in our laboratories is to increase the knowledge of health and disease, and improve the well-being of the population at large by preventing and counteracting disease. Towards this goal, researchers are expected to share their findings in an expedited and open fashion via timely publications in high-impact peer reviewed journals, such as the Journal of Investigative Dermatology. In fact, several funding agencies, including the National Institutes of Health, require that papers emanating from research funded by them be made available to the public soon after publication.
The Society for Investigative Dermatology wishes to acknowledge the generous support of the following individuals and organizations.